NR4A1 Ovarian Cancer
Epithelial ovarian cancer is the most lethal gynecologic malignancy and the fifth most common cause of cancer related deaths in women in the United States. Recently, NR4A1 has been identified as a potential driver of ovarian cancer pathogenesis (Delgato et al. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecology Oncology, 2016, 141:348-356). In collaboration with Dr. Steffi Oesterreich at the Women’s Cancer Research Center we are applying heterogeneity analysis to a high content screen to identify compounds that modulate the intracellular location and function of NR4A1, and which can be used to characterize the role of NR4A1 in ovarian cancer.