Lawrence Vernetti, PhD

Research Associate Professor, Dept. of Computational and Systems Biology, Director of Early Drug Safety, University of Pittsburgh Drug Discovery Institute

Lawrence Vernetti, PhD

Vernetti@pitt.edu

Office: W958 BST
Phone: 412-624-5425
Fax:

Department of Computational and Systems Biology

 

MS in Toxicology, University of Arizona
PhD in Pharmacology/Toxicology, University of Arizona

My research focus is in the application of early drug safety testing using a variety of in vitro, in vivo and in silico methodologies. In particular, I am a member of the Liver Microphysiology Systems (MPS) program where we are developing advanced 3D multicellular microfluidic livers for testing drug efficacy, toxicity and disease models. I also curate toxicology literature for animal and human drug trials information for entry into the MPS database, a web based program to design, manage, mine and model in vitro data to correlate with pre-clinical and clinical findings. Finally, my research interests extend to exploiting recent advances in iPSC derived hepatocytes in the Liver MPS to advance the study of various human liver diseases.

  1. Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. 2017. Sci Rep. Feb 8;7:42296. PubMed PMID: 28176881
  2. Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.Lee-Montiel F, George S, Gough A and Taylor DL. (2017). Expt Biol Med (April) DOI: 10.1177/1535370217703978
  3. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. Clinics in liver disease.Vernetti LA, Vogt A, Gough A, Taylor DL. 2017;21(1):197-214.
  4. Organs-on-Chips as Bridges for Predictive Toxicology. Applied In Vitro Toxicology. M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen,Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A. Vernetti, and John P. Wikswo. Applied In Vitro Toxicology 2.2 (2016): 97-102.
  5. "The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models."Gough Albert, Vernetti Lawrence, Bergenthal Luke, Shun Tong Ying, and Taylor D. Lansing Applied In Vitro Toxicology 2.2 (2016): 103-117.
  6. A Human Liver Microphysiology Platform for Investigating Physiology, Drug Safety and Disease Models. Vernetti L*, Senutovitch N*, Boltz R, DeBiasio R, Gough A, Shun TY, Taylor DL (*co-first authors). Exp Biol Med, 2016 Jan; 241.1: 101-114.
  7. Fluorescent Protein Biosensors Applied to Microphysiological Systems. Senutovitch N*, Vernetti L*, Boltz R, DeBiasio R, Gough A, Taylor DL (*co-first authors). 2015 Exp Biol Med, 2015 Jun;240(6):795-808.