Acute Kidney Injury


The vertebrate kidney has an innate ability to regenerate after acute kidney injury (AKI) that is highly conserved across species.  During regeneration, the same transcription factors normally expressed during organogenesis are reactivated.  With Dr. Neil Hukriede, Department of Developmental Biology, we are using high throughput screening in zebrafish embryos to discover  molecules that activate organogenesis, and have found agents that ameliorate recovery from AKI and reduce fibrosis in mouse models when administered days after the injury has occurred (Sanker  et al. Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish. J Biomol Screen. 2013;18:1193-202, Skrypnyk et al. Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury. Am J Physiol Renal Physiol. 2015:ajprenal 00503 2015).