UPDDI Core Facilities and Equipment

Chemical Biology Facility


The Chemical Biology Facility (ChBF) is a cancer-focused component of the University of Pittsburgh Drug Discovery Institute, and one of the National Cancer Institute (NCI)-supported Shared Resources of the University of Pittsburgh Cancer Institute (UPCI). In this capacity, ChBF faculty and staff collaborate with UPCI investigators to:


  • Guide the design of effective drug discovery projects or programs for the discovery of novel cancer therapeutics;
  • Provide access to the state-of –the-art use of QSP in implementing novel drug discovery programs;
  • Provide assistance to designing, developing, and implementing cost effective screening assays;
  • Provide access to compound libraries for probe and lead identification;
  • Assist in early toxicity assays for profiling compounds.


Drawing from UPDDI’s many technical and intellectual strengths the ChBF also provides support for hit characterization and lead optimization and informatics for data analysis and interpretation including computational mining of public databases. The ChBF is designed to play a vital role in numerous research projects in oncology by providing UPCI members with access to state-of-the-art reagents and instrumentation (see Facilities) that are not readily available elsewhere at the University of Pittsburgh or at UPCI. The ChBF also assists investigators with connections to the pharmaceutical industry.