Chemical Proteomics

Integral to Quantitative Systems Pharmacology is the use of phenotypic models of disease progression.  Compounds modulating pathways in these models yield a systems response potentially involving multiple pathways.  In collaboration with the Biomedical Mass Spectrometry Center we are implementing novel approaches in chemical proteomics to identify compound targets in phenotypic systems.  Using this cutting-edge technology we have the capability of identifying both soluble and membrane bound targets.