UPDDI Core Facilities and Equipment

Chemistry/Medicinal Chemistry Facility

UPDDI has access to chemistry and medicinal chemistry laboratories at the University of Pittsburgh Department of Chemistry and at the University of Pittsburgh School of Pharmacy. The chemistry and medicinal chemistry facilities available to UPDDI are located in the University of Pittsburgh Oakland campus at the BST3, Chevron and Salk Hall buildings. The chemistry/medicinal chemistry facilities are equipped with the state-of-the art analytical instrumentation including seven 400-600 MHz Bruker NMRs (Salk, Chevron, BST3), two ATR FTIRs (1 Chevron, 1 Salk), four LCMS systems (2 Chevron, 2 BST3), and a circular dichroism system (Chevron). Other equipment available are a Waters SFC purification instrument (BST3), four Isco Combiflash purification systems (3 Chevron, 1 BST3) and prep HPLCs (Chevron, Salk), two Emrys microwave reactors (1 Chevron, 1 Salk), two Par hydrogenators (1 Chevron, 1 Salk), two lyophilizers (1 Chevron, 1 Salk), a Flexicool cooling system and a cold room for low temp reactions (Chevron). The available equipment and facilities allow UPDDI access to non-GLP pharmaceutically relevant compounds from milligram to multi-gram scale.