Matthew LaPorte, Ph.D.

Associate Professor, Department of Chemistry; Assistant Director, UPCMLD

Matthew LaPorte, Ph.D.

Phone: 412-624-8004

Department of Chemistry


Ph.D. in Organic Chemistry, The Pennsylvania State University

My research focus is the discovery, design, and synthesis of small molecule drug candidates as new anti-cancer agents.  These medicinal chemistry efforts cover hit-to-lead, lead optimization, and scale-up efforts within various collaborative drug discovery projects.  

  1. Alverez, C.; Bulfer, S.L.; Chakrasali, R.; Chimenti, M.S.; Deshaies, R.J.; Green, N.; Kelly, M.; LaPorte, M.G.; Lewis, T.S.; Liang, M.; Moore, W.J.; Neitz, R.J.; Peshkov, V.A.; Walters, M.A.; Zhang, F.; Arkin, M.R.; Wipf, P.; Huryn, D.M. “Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.” ACS Med. Chem. Lett. 2016, 7, 182-187.
  2. Alverez, C.; Arkin, M.R.; Bulfer, S.L.; Colombo, R.; Kovaliov, M.; LaPorte, M.G.; Lim, C.; Liang, M.; Moore, W.J.; Neitz, R.J.; Yan, Y.; Yue, Z.; Huryn, D.M.; Wipf, P. “Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.” ACS Med. Chem. Lett. 2015, 6, 1225-1230.
  3. LaPorte, M.G.; Lima, D.J.; Zhang, F.; Sen, M.; Grandis, J.R.; Camarco, D.; Hua, Y.; Johnston, P.A.; Lazo, J.S.; Resnick, L.O.; Wipf, P.; Huryn, D.M. “2-Guanidinoquinazolines as new inhibitors of the STAT3 Pathway.” Bioorg. Med. Chem. Lett. 2014, 24, 5081-5085.