Tim Lezon, PhD

Group Leader of Systems Biology and Modeling, Assistant Professor of Computational and Systems Biology

Tim Lezon, PhD

lezon@pitt.edu

Office: W956 BST
Phone: 412.383.8042
Fax:

Department of Computational and Systems Biology

PhD in physics, The Pennsylvania State University

The single-target view of drug discovery is yielding to a systems-based view in which drugs are used in combinations to alter the behavior of specific and multiple pathways. This approach, called Quantitative Systems Pharmacology (QSP) requires the seamless integration of computational modeling and experiments. Among the computational challenges of QSP are identifying pathways relevant to disease and outlining the mechanistic details of those pathways. My lab is developing methods for inferring disease pathways from screening data, and is constructing mechanistic models of pathways that are central to the progression of cancer and other diseases. We are developing methods to predict the outcomes of phenotypic screens, including how cells will respond to combinations of two or more drugs.

  1. Erdem C, Nagle AM, Casa AJ, Litzenburger BC, Wang Y, Taylor DL, Lee AV and Lezon TR. Proteomic screening and lasso regression reveal differential signaling in insulin and insulin-like growth factor I pathways. Molecular and Cellular Proteomics M115.057729 (2016, in press).
  2. Gough A, Chen N, Schurdak M, Shun TY, Lezon T, Boltz R, Reese C, Wagner J, Vernetti L, Grandis J, Lee A and Taylor DL. Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery. PLoS ONE 9:e102678 (2014). PMID: 4103836
  3. Bakan A, Dutta A, Mao W, Liu Y, Chennubhotla C, Lezon TR and Bahar I. Evol and ProDy for bridging protein sequence evolution and structural dynamics. Bioinformatics 30:2681-2683 (2014). PMID: 24849577
  4. Lezon TR and Bahar I. Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh. Biophys J 102:1331-1340 (2012). PMID: 22455916
  5. Lezon TR. The effects of rigid motions on elastic network model force constants. Proteins 80:1133-1142 (2012). PMID: 22228562