QSP programs

Liver Diseases


We have developed a platform that includes a human, 4 cell, microfluidic, 3D liver microphysiological system to investigate human toxicology and liver diseases (Vernetti et. al. A human liver microphysiology platform for investigating physiology, drug ‘safety and disease models. J. Expt. Biol and Med. 2016; 241: 101-114).  We are supported by the NIH/NCATS and the EPA.  Experimental models of liver diseases include non-alcoholic fatty liver disease, a variety of rare childhood liver diseases, metastatic site for metastatic breast cancer and hepatocarcinoma.