Lee McDermott, PhD, MBA

Assistant Professor, Pharmaceutical Sciences

Lee McDermott, PhD, MBA

Lam179@pitt.edu

Office:
Phone: 412-383-5300
Fax:

School of Pharmacy

PhD, Brown University; MBA, Rutgers University

My research focus is medicinal chemistry, rational drug design and optimization of small molecules against enzyme targets important in tumor cell metabolism, immuno-oncology and neuronal injury pathways.

  1. McDermott LA, Iyer P, Vernetti L, Rimer S, Sun J, Boby M, Yang T, Fioravanti M, O'Neill J, Wang L, Drakes D, Katt W, Huang Q, Cerione R. (2016). “Design and evaluation of novel glutaminase inhibitors” Bioorg. Med. Chem., 24(8), 1819-39.
  2. Marani, M.; Paone, A.; Fiascarelli, A.; Macone, A.; Gargano, M.; Rinaldo, S.; Giardina, G.; Pontecorvi, V.; Koes, D.; McDermott, L.; Yang, T.; Paiardini, A.; Contestabile, R.; Cutruzzolà, F. (2016) “A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells” Oncotarget. 7(4), 4570-4583.
  3. Skrypnyk, N.I.; Sanker, S.; Brilli-Skvarca, L.; Novitskaya, T.; Woods, C.; Chiba, T.; Patel, K.; Goldberg, N.D.; McDermott, L.; Vinson, P.N.; Calcutt, M.W.; Huryn, D.M.; Vernetti, L.A.; Vogt, A.; Hukriede, N.; deCaestecker, M.P. (2016) “Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury”. Am J Physiol Renal Physiol. 310 (8), F705-F716
  4. Paiardini, A,.; Fiascarelli, A.; Rinaldo, S.; Daidone, F.; Giardina, G.; Koes, D.R.; Parroni, A.; Montini, G.; Marani, M.; Paone, A.; McDermott, L.A.; Contestabile, R.; Cutruzzolà, F. (2015). “Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.” ChemMedChem 10, 490-497.
  5. McDermott, L.; Qin, C. (2015) “Allosteric MeK Inhibitors for the Treatment of Cancer. An Overview” J. Drug Res. Dev., 1 (1): doi.org/10.16966/jdrd.101