Publications

A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX. Li, X, S.M. George, L. Vernetti, A.H. Gough and D.L. Taylor; Lab Chip, 2018. Jul 31. doi: 10.1039/c8lc00418h

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A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes. Schurdak, M.E., F. Pei, T.R. Lezon, D. Carlisle, R. Friedlander, D.L. Taylor and A.M. Stern; Methods Mol Biol, 2018. 1787: p. 207-222. doi: 10.1007/978-1-4939-7847-2_16.

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A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Saydmohammed, M, L.L. Vollmer, E.O. Onuoha, T.S. Maskrey, G. Gibson, S.C. Watkins, P. Wipf, A. Vogt and M. Tsang; Molecules (Basel, Switzerland) 2018 Jul 11;23(7). PubMed PMID: 29997348. Epub 2018/07/13.

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Liver 'organ on a chip'. Beckwitt, C.Hh, A.M. Clark, S. Wheeler, D.L. Taylor, D.B. Stolz, L. Griffith and A. Wells; Exp Cell Res, 2018. 363(1): p. 15-25.

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Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies; Gough, A., T.Y Shun, D.L. Taylor and M. Schurdak; Methods Mol Biol, 2018. 1745: p. 25-46.

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Clinically observed estrogen receptor alpha mutations within the ligand-binding domain confer distinguishable phenotypes. Jia, S., M.T. Miedel, M. Ngo, R. Hessenius, N. Chen, P. Wang, A. Bahreini, Z. Li, Z. Ding, T.Y. Shun, D.M. Zuckerman, D.L. Taylor, S.L. Puhalla, A.V. Lee, S. Oesterreich, and A.M. Stern; Oncology, 2018. 94: p. 176-189. 

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Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Keating, S.M, D.L. Taylor, A.L. Plant, E.D. Litwack, P. Kuhn, E.J. Greenspan, C.M. Hartshorn, C.C. Sigman, G.J. Kelloff, D.D. Change, G. Friberg, J.S.H. Lee and K. Kuida; Clin Transl Sci, 2018.

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High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Johnston, P.A., M. Sen, Y. Hua, D. Camarco, T. Shun, J. Lazo and J. Grandis. Methods Mol Biol, 2018. 1683: p. 229-244.

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Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology; Pei, F., H. Li, M. J. Henderson, S.A. Titus, A. Jadhav, A. Simeonov, M.C. Cobanoglu, S.H. Mousavi, T. Shun, L. McDermott, P. Iyer, M. Fioravanti, D. Carlisle, R.M. Friedlander, I. Bahar, D.L. Taylor, T.R. Lezon, A.M. Stern and M.E. Schurdak; Sci Rep, 2017. 7(1): p. 17803.

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Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images; Spagnolo, D.M., Y. Al-Kofahi, P. Zhu, T.R. Lezon, A. Gough, A.M. Stern, A.V. Lee, F. Ginty, B. Sarachan, D.L. Taylor and S.C. Chennubhotla; Cancer Res, 2017. 77(21): p. e71-e74.

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Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems; Lee-Montiel, F.T., S. George, A.H. Gough, A.D. Sharma, J. Wu, R. DeBiasio, L.A. Vernetti and D.L. Taylor. Exp Biol Med (Maywood), 2017. 242(16): p. 1617-1632.

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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release; Suofu, Y., w. Li, F.G. Jean-Alphonse, J. Jia, N.K. Khattar, J. Li, S.V. Baranov, D. Leronni, A.C. Mihalik, Y. He, E. Cecon, V.L. Wehbi, J. Kim, B.E. Heath, O.V. Baranova, X. Wang, M.J. Gable, E.S. Kretz, G. Di Benedetto, T.R. Lezon, L. Ferrando, T.M. Larkin, M. Sullivan, S. Yablonska, J. Wang, M.B. Minnigh, G. Guillaumet, F. Suzenet, R.M. Richardson, S.M. Poloyac, D.B. Stolz, R. Jockers, P.A. Witt-Enderby, D.L. Carlisle, J. Vilardaga and R.M. Friedlander; Proc Natl Acad Sci U S A, 2017. 114(38): p. E7997-E8006.

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Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos. Shun, T., A.H. Gough, S. Subramaniam, N.A. Hukriede and A. Vogt; Assay Drug Dev Technol, 2017. 15(6): p. 257-266.

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Architectural Patterns for Differential Diagnosis of Proliferative Breast Lesions from Histopathological Images. Nguyen, L., A.B. Tosun, J.L. Fine, D.L. Taylor and S.C. Chennubhotla; Proc IEEE Int Symp Biomed Imaging, 2017. 2017: p. 152-155.

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Comparison of three cell-based drug screening platforms for HSV-1 infection; D'Aiuto, L., K. Williamson, P. Dimitrion, J. McNulty, C.E. Brown, C.B. Dokuburra, A.J. Nielsen, W.J. Lin, P. Piazza, M.E. Schurdak, J. Wood, R.H., Yolken, P.R. Kinchington, D.C. Bloom and V.L. Nimgaonkar; Antiviral Res, 2017. 142: p. 136-140.

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Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems; Soto-Gutierrez, A., A. Gough, L.A. Vernetti, D.L. Taylor and S.P. Monga; Exp Biol Med (Maywood), 2017: p. 1535370217707731.

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A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. Kaltenmeier, C.T., L.L. Vollmer, L.A. Vernetti, L. Caprio, K. Davis, V.N. Korotchenko, B.W. Day, M. Tsang, K.I, Hulkower, M.T. Lotze and A. Vogt; J Pharmacol Exp Ther, 2017. 361(1): p. 39-50.

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Spatial statistics for segmenting histological structures in H&E stained tissue images; Nguyen, L., A.B. Tosun, J.L. Fine, A.V. Lee, D.L. Taylor and S.C. Chennubhotla; IEEE Trans Med Imaging, 2017.

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Modeling global changes induced by local perturbations to the HIV-1 capsid; Bergman, S. and T.R. Lezon; J Mol Graph Model, 2017. 71: p. 218-226.

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Biologically Relevant Heterogeneity: Metrics and Practical Insights; Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL; (2017) SLAS discovery 22 (3):213-237. doi:10.1177/2472555216682725

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Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy; Vernetti LA, Vogt A, Gough A, Taylor DL (2017); Clinics in liver disease 21 (1):197-214. doi:10.1016/j.cld.2016.08.013

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Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle; Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL (2017) ;Scientific reports 7:42296. doi:10.1038/srep42296

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Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models; Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S (2017); Breast cancer research : BCR 19 (1):60. doi:10.1186/s13058-017-0851-4

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Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury; Hukriede N, Vogt A, de Caestecker M (2017);  Nephron. doi:10.1159/000476079

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Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways; Cemal Erdem, Alison M. Nagle, Angelo J. Casa, Beate C. Litzenburger, Yu-fen Wang, D. Lansing Taylor, Adrian V. Lee, and Timothy R. Lezon; Molecular & Cellular Proteomics, 2016, pp.mcp-M115
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High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome; Delgado, E., M.M. Boisen, R. Laskey, R. Chen, C. Song, J. Sallit, Z.A. Yochum, C.L. Andersen, M.J. Sikora, J. Wagner, S. Safe, E. Elishaev, A. Lee, R.P. Edwards, P. Haluska, G. Tseng, M. Schurdak, and S. Oesterreich; Gynecology Oncology, 2016, 141: p. 348-356
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A human liver microphysiology platform for investigating physiology, drug safety, and disease models; Vernetti, L.A., N. Senutovitch, R. Boltz, R. DeBiasio, T. Ying Shun, A. Gough, and D.L. Taylor; Exp Biol Med (Maywood), 2016. 241(1): p. 101-14
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A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine; Stern, A.M., M.E. Schurdak, I. Bahar, J.M. Berg, and D.L. Taylor; Journal of Biomolecular Screening, 2016. 21(6): p. 521-534
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Pointwise Mutual Information Quantifies Intra-Tumor Heterogeneity in Tissue Sections Labeled with Multiple Fluorescent Biomarkers; Spagnolo, D.M., R. Gyanchandani, Y. Al-Kofahi, T. Lezon, A. Gough, D.E. Meyer, F. Ginty, B. Sarachan, J. Fine, A.V. Lee, D.L. Taylor, and S.C. Chennubhotla; Journal of Pathology Informatics, 2016. In press.
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The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models; Gough, A., L. Vernetti, L. Bergenthal, T.Y. Shun, and D.L. Taylor; Applied In Vitro Toxicology, 2016. 2(2): p. 103-117
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A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens; Gough, A., T.Y. Shun, D. Lansing Taylor, and M. Schurdak; Methods, 2016. 96: p. 12-26
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Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers; Gearhart, T.L., R.C. Montelaro, M.E. Schurdak, C.D. Pilcher, C.R. Rinaldo, T. Kodadek, Y. Park, K. Islam, R. Yurko, E.T. Marques, Jr., and D.S. Burke; J Immunol Methods, 2016. 435: p. 85-9
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Fluorescent protein biosensors applied to microphysiological systems; Senutovitch, N., L. Vernetti, R. Boltz, R. DeBiasio, A. Gough, and D.L. Taylor; Exp Biol Med (Maywood), 2015. 240: p. 795–808
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High-Content Analysis with Cellular and Tissue Systems Biology: a Bridge between Cancer Cell Biology and Tissue-Based Diagnostics; Gough, A., T. Lezon, J.R. Faeder, C. Chennubhotla, R.F. Murphy, R. Critchley-Thorne, and D.L. Taylor; in The molecular basis of cancer, J. Mendelsohn, et al., Editors. 2015, Saunders/Elsevier: Philadelphia, PA. p. 369-392.
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A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities; Joy, M.E., L.L. Vollmer, K. Hulkower, A.M. Stern, C.K. Peterson, R.C. Boltz, P. Roy, and A. Vogt; PLoS One, 2014. 9(2): p. e88350
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Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery; Gough, A.H., N. Chen, T.Y. Shun, T.R. Lezon, R.C. Boltz, C.E. Reese, J. Wagner, L.A. Vernetti, J.R. Grandis, A.V. Lee, A.M. Stern, M.E. Schurdak, and D.L. Taylor; PLoS One, 2014. 9(7): p. e102678
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Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation; D'Aiuto, L., Y. Zhi, D. Kumar Das, M.R. Wilcox, J.W. Johnson, L. McClain, M.L. MacDonald, R. Di Maio, M.E. Schurdak, P. Piazza, L. Viggiano, R. Sweet, P.R. Kinchington, A.G. Bhattacharjee, R. Yolken, and V.L. Nimgaonkar; Organogenesis, 2014. 10(4): p. 365-77
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