Publications

Biologically Relevant Heterogeneity: Metrics and Practical Insights; Gough A, Stern AM, Maier J, Lezon T, Shun TY, Chennubhotla C, Schurdak ME, Haney SA, Taylor DL; (2017) SLAS discovery 22 (3):213-237. doi:10.1177/2472555216682725

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Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy; Vernetti LA, Vogt A, Gough A, Taylor DL (2017); Clinics in liver disease 21 (1):197-214. doi:10.1016/j.cld.2016.08.013

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Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle; Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL (2017) ;Scientific reports 7:42296. doi:10.1038/srep42296

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Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models; Bahreini A, Li Z, Wang P, Levine KM, Tasdemir N, Cao L, Weir HM, Puhalla SL, Davidson NE, Stern AM, Chu D, Park BH, Lee AV, Oesterreich S (2017); Breast cancer research : BCR 19 (1):60. doi:10.1186/s13058-017-0851-4

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Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury; Hukriede N, Vogt A, de Caestecker M (2017);  Nephron. doi:10.1159/000476079

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Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways; Cemal Erdem, Alison M. Nagle, Angelo J. Casa, Beate C. Litzenburger, Yu-fen Wang, D. Lansing Taylor, Adrian V. Lee, and Timothy R. Lezon; Molecular & Cellular Proteomics, 2016, pp.mcp-M115
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High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome; Delgado, E., M.M. Boisen, R. Laskey, R. Chen, C. Song, J. Sallit, Z.A. Yochum, C.L. Andersen, M.J. Sikora, J. Wagner, S. Safe, E. Elishaev, A. Lee, R.P. Edwards, P. Haluska, G. Tseng, M. Schurdak, and S. Oesterreich; Gynecology Oncology, 2016, 141: p. 348-356
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A human liver microphysiology platform for investigating physiology, drug safety, and disease models; Vernetti, L.A., N. Senutovitch, R. Boltz, R. DeBiasio, T. Ying Shun, A. Gough, and D.L. Taylor; Exp Biol Med (Maywood), 2016. 241(1): p. 101-14
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A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine; Stern, A.M., M.E. Schurdak, I. Bahar, J.M. Berg, and D.L. Taylor; Journal of Biomolecular Screening, 2016. 21(6): p. 521-534
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Pointwise Mutual Information Quantifies Intra-Tumor Heterogeneity in Tissue Sections Labeled with Multiple Fluorescent Biomarkers; Spagnolo, D.M., R. Gyanchandani, Y. Al-Kofahi, T. Lezon, A. Gough, D.E. Meyer, F. Ginty, B. Sarachan, J. Fine, A.V. Lee, D.L. Taylor, and S.C. Chennubhotla; Journal of Pathology Informatics, 2016. In press.
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The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models; Gough, A., L. Vernetti, L. Bergenthal, T.Y. Shun, and D.L. Taylor; Applied In Vitro Toxicology, 2016. 2(2): p. 103-117
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A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens; Gough, A., T.Y. Shun, D. Lansing Taylor, and M. Schurdak; Methods, 2016. 96: p. 12-26
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Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers; Gearhart, T.L., R.C. Montelaro, M.E. Schurdak, C.D. Pilcher, C.R. Rinaldo, T. Kodadek, Y. Park, K. Islam, R. Yurko, E.T. Marques, Jr., and D.S. Burke; J Immunol Methods, 2016. 435: p. 85-9
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Fluorescent protein biosensors applied to microphysiological systems; Senutovitch, N., L. Vernetti, R. Boltz, R. DeBiasio, A. Gough, and D.L. Taylor; Exp Biol Med (Maywood), 2015. 240: p. 795–808
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High-Content Analysis with Cellular and Tissue Systems Biology: a Bridge between Cancer Cell Biology and Tissue-Based Diagnostics; Gough, A., T. Lezon, J.R. Faeder, C. Chennubhotla, R.F. Murphy, R. Critchley-Thorne, and D.L. Taylor; in The molecular basis of cancer, J. Mendelsohn, et al., Editors. 2015, Saunders/Elsevier: Philadelphia, PA. p. 369-392.
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A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities; Joy, M.E., L.L. Vollmer, K. Hulkower, A.M. Stern, C.K. Peterson, R.C. Boltz, P. Roy, and A. Vogt; PLoS One, 2014. 9(2): p. e88350
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Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery; Gough, A.H., N. Chen, T.Y. Shun, T.R. Lezon, R.C. Boltz, C.E. Reese, J. Wagner, L.A. Vernetti, J.R. Grandis, A.V. Lee, A.M. Stern, M.E. Schurdak, and D.L. Taylor; PLoS One, 2014. 9(7): p. e102678
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Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation; D'Aiuto, L., Y. Zhi, D. Kumar Das, M.R. Wilcox, J.W. Johnson, L. McClain, M.L. MacDonald, R. Di Maio, M.E. Schurdak, P. Piazza, L. Viggiano, R. Sweet, P.R. Kinchington, A.G. Bhattacharjee, R. Yolken, and V.L. Nimgaonkar; Organogenesis, 2014. 10(4): p. 365-77
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