F. Raymond Salemme, PhD

CEO Imiplex LLC of Arizona

F. Raymond Salemme, PhD


Phone: (215) 962.2642



BA, Molecular Biophysics, Yale 1967
PhD, Chemistry (Protein Crystallography) UCSD 1972
Post Doc, Martin Kamen (Electron Transport Mechanisms) UCSD 1973
Sabbatical, Fred Richards (Protein Structure Theory) Yale 1981

Ray Salemme is a scientist-entrepreneur who has worked in both academia and industry. Originally trained as an X-ray crystallographer, he pioneered the development of structural and biophysical methods for protein engineering and drug discovery. His academic work focused on the 3D structure determination of proteins and exploration of the factors that lead to the recurrence of protein structural motifs. Dr. Salemme joined one of the first biotechnology companies, Genex, to establish its Protein Engineering Division in 1982. Subsequently he built and directed multidisciplinary scientific groups DuPont Central Research, DuPont Merck Pharmaceuticals, and Sterling Winthrop Pharmaceuticals. In 1993 he founded 3-Dimensional Pharmaceuticals, a biotechnology company that integrated structure-based drug design and combinatorial chemistry, that was subsequently acquired by Johnson & Johnson. Dr. Salemme founded Imiplex in 2004 to develop nanotechnology applications based on engineered proteins. Dr. Salemme has authored over 100 scientific publications and is an inventor on 41 US Patents, covering nanotechnology, computational methods for drug discovery, engineered proteins, and instrumentation for high throughput screening and protein characterization. Dr. Salemme holds a BA in Molecular Biophysics from Yale University and a PhD in Chemistry from UCSD. www.beta-sheet.org.

  1. Weber PC, Ohlendorf DH, Wendoloski JJ, Salemme FR. Structural origins of high-affinity biotin binding to streptavidin. Science. 1989 Jan 6;243(4887):85-8. PubMed PMID: 2911722. (1077 Citations 07/13/16)
  2. Pantoliano MW, Petrella EC, Kwasnoski JD, Lobanov VS, Myslik J, Graf E, Carver T, Asel E, Springer BA, Lane P, Salemme FR. High-density miniaturized thermal shift assays as a general strategy for drug discovery. J Biomol Screen. 2001 Dec;6(6):429-40. PubMed PMID: 11788061. (535 citations 07/13/16)
  3. Howard AJ, Gilliland GL, Finzel BC, Poulos TL, Ohlendorf DH, and Salemme FR. Use of an Imaging Proportional Counter in Macromolecular Crystallography. J. Appl. Cryst. 1987; 20: 383-387 (528 citations 07/13/16)
  4. Salemme FR. An hypothetical structure for an intermolecular electron transfer complex of cytochromes c and b5. J Mol Biol 1976 Apr 15;102(3):563-8. PubMed PMID: 178879. (350 citations 07/13/16)
  5. Agrafiotis DK, Bone RF, Salemme FR, Soll RM. System and method of automatically generating chemical compounds with desired properties (1995) US Patent 5,463,564 (246 citations 07/13/16)