Lawrence Vernetti, PhD

Director of Early Drug Safety, Drug Discovery Institute, Associate Professor of Computational and Systems Biology

Lawrence Vernetti, PhD

Vernetti@pitt.edu

Office: W958 BST
Phone: 412-624-5425
Fax:

Department of Computational and Systems Biology

MS in Toxicology, University of Arizona
PhD in Pharmacology/Toxicology, University of Arizona

My research focus is in the application of early drug safety testing using a variety of in vitro, in vivo and in silico methodologies. In particular, I am a member of the Liver Microphysiology Systems (MPS) program where we are developing advanced 3D multicellular microfluidic livers for testing drug efficacy, toxicity and disease models. I also curate toxicology literature for animal and human drug trials information for entry into the MPS database, a web based program to design, manage, mine and model in vitro data to correlate with pre-clinical and clinical findings. Finally, my research interests extend to exploiting recent advances in iPSC derived hepatocytes in the Liver MPS to advance the study of various human liver diseases.

  1. M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen,Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A. Vernetti, and John P. Wikswo. Organs-on-Chips as Bridges for Predictive Toxicology. Applied In Vitro Toxicology. Applied In Vitro Toxicology 2.2 (2016): 97-102.
  2. Gough Albert, Vernetti Lawrence, Bergenthal Luke, Shun Tong Ying, and Taylor D. Lansing "The Microphysiology Systems Database for Analyzing and Modeling Compound Interactions with Human and Animal Organ Models." Applied In Vitro Toxicology 2.2 (2016): 103-117.
  3. Vernetti L*, Senutovitch N*, Boltz R, DeBiasio R, Gough A, Shun TY, Taylor DL (*co-first authors). A Human Liver Microphysiology Platform for Investigating Physiology, Drug Safety and Disease Models. Exp Biol Med, 2016 Jan; 241.1: 101-114.
  4. Senutovitch N*, Vernetti L*, Boltz R, DeBiasio R, Gough A, Taylor DL (*co-first authors). Fluorescent Protein Biosensors Applied to Microphysiological Systems. 2015 Exp Biol Med, 2015 Jun;240(6):795-808.
  5. *Vernetti L, *Bale SS, Senutovitch N , Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta OB, Yarmush ML, Taylor DL (*co-first authors), In vitro platforms for evaluating liver toxicity. 2014 Exp Biol Med Sep;239(9):1180-91.