Andreas Vogt, PhD

Group Leader Small Organism Discovery, Drug Discovery Institute, Associate Professor of Computational and Systems Biology

Andreas Vogt, PhD

avogt@pitt.edu

Office: W948 BST
Phone: 412-383-5856
Fax:

Department of Computational and Systems Biology

PhD, Pharmaceutical Chemistry; B.S. Pharmacy,  University of Hamburg, Germany

My major research interest is the discovery of new therapeutic agents for diseases related to cell proliferation and intra- and extracellular signaling. Specific targets of interest are mitogen-activated protein kinase phosphatases (MKPs) and histone deacetylases, cellular enzymes involved in cancer, regeneration, and immunity that have largely eluded discovery efforts. An important part of my research is the development of analysis tools to increase information content of biological assays and to enable small molecule drug discovery in multidimensional cell systems and whole multicellular organisms such as zebrafish.

  1. Sanker S, Cirio MC, Vollmer LL, Goldberg ND, McDermott LA, Hukriede NA, Vogt A. Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish. J Biomol Screen. 2013;18(10):1193-202. (Featured in Special Issue Phenotypic Drug Discovery) Joy ME, Vollmer, LL, Hulkower, KI, Stern, AM, Roy, P, Vogt A. (2014) A high content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities. PLoS One 2014;9(2):e88350. Korotchenko, VN, Saydmohammed M, Vollmer LL, Bakan A, Sheetz K, Debiec KT, Greene KA, Agliori, CS, Bahar I, Day BW., Vogt A, Tsang M. In Vivo Structure-Activity Relationship Studies Support Allosteric Targeting of a Dual Specificity Phosphatase. Chembiochem 15(10): 1436-1445 (2014). Li M, Yang Z, Vollmer LL, Gao Y, Fu Y, Liu C, Chen X, Liu P, Vogt A, Yin XM. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083. doi: 10.1371/journal.pone.0122083. eCollection 2015. Skrypnyk NI, Sanker S, Brilli-Skvarca L, Novitskaya T, Woods C, Chiba T, Patel K, Goldberg ND, McDermott L, Vinson PN, Calcutt MW, Huryn DM, Vernetti LA, Vogt A, Hukriede N, de Caestecker MP. Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury. Am J Physiol Renal Physiol. 2015:ajprenal 00503 2015.